Preconditioning by 5-min forebrain ischemia reduced brain edema and cell damage following 15-min forebrain ischemia in gerbils.
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منابع مشابه
Propofol prevents lipid peroxidation following transient forebrain ischemia in gerbils.
PURPOSE To ascertain whether propofol prevents lipid peroxidation on delayed neuronal death induced by transient forebrain ischemia in the hippocampal CA1 subfield in gerbils. METHODS Forty gerbils were randomly assigned to five groups: Group I, control, sham operation treated with physiological saline solution (PSS); Group II, ischemia/reperfusion treated with PSS; Group III, ischemia/reperf...
متن کاملCDP-choline: neuroprotection in transient forebrain ischemia of gerbils.
CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. The ability of CDP-choline to alter phospholipid metabolism is an important function in the treatment of ischemic injury. Exogenous treatment with CDP-choline stimulates PtdCho synthesis and prevents release of free fatty acids (FFA), especially ar...
متن کاملLY178002 reduces rat brain damage after transient global forebrain ischemia.
Several feasible mechanisms have been proposed as sources of neuronal damage from ischemia and subsequent reperfusion. Included among these are oxidative damage caused by free radical production and lipid peroxidation and products derived from phospholipid breakdown. A series of 4-thiazolidinone compounds represented by LY178002 (5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene-4-thiazol...
متن کاملReduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia.
BACKGROUND AND PURPOSE Preischemic spontaneous locomotor activity was distinguished in this laboratory as a factor influencing outcome after 15 and 20 minutes of forebrain ischemia in gerbils. Histological investigations were carried out to analyze potential relations between postischemic survival and a reduction of cerebral damage by spontaneous locomotor activity. METHODS Male Mongolian ger...
متن کاملTime course of early brain edema following reversible forebrain ischemia in rats.
Cerebral ischemia is known to be accompanied by brain edema. This increase in brain tissue water content probably influences the final outcome of an ischemic insult negatively. Despite extensive investigations on different aspects of brain edema, information on edema development during the early recirculation period following ischemia is sparse. We assessed changes in brain water content, as re...
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ژورنال
عنوان ژورنال: Nosotchu
سال: 1998
ISSN: 0912-0726,1883-1923
DOI: 10.3995/jstroke.20.258